泰脂安胶囊治疗150例血脂异常患者的临床观察

目的 :了解泰脂安调节血脂的疗效。方法 :30 0例血脂异常患者 ,按随机数字表方法分为 7个组 ,泰脂安组 90例 ,半量非诺贝特加泰脂安组 30例 ,全量非诺贝特组 30例 ,半量辛伐他汀加泰脂安组 30例 ,全量辛伐他汀组 30例 ,脂必妥组 6 0例 ,血脂康组 30例 ,治疗 8周后比较疗效。结果 :泰脂安组胆固醇 (TC)下降 12 7% ,甘油三酯 (TG)下降 2 2 1% ,高密度脂蛋白胆固醇 (HDL C)上升 13 1% ,低密度脂蛋白胆固醇(LDL C)下降 14 0 % ,总有效率为 82 %。半量非诺贝特加泰脂安组与全量非诺贝特组比较 ,疗效相似 (P >0 0 5 ) ;半量辛伐他汀加泰脂安组与全量辛伐他汀组比较 ,疗效相似 (P >0 0 5 )。泰脂安与血脂康组、脂必妥组比较 ,疗效相似 (P >0 0 5 ) ,但在降低TG、LDL C、升高HDL C方面优于脂必妥组 (P <0 0 5 ) ,在降TG、升HDL C方面优于血脂康组 (P <0 0 5 )。结论 :半量辛伐他汀 (或非诺贝特 )加泰脂安调节血脂效果好。泰脂安与血脂康、脂必妥组比较 ,疗效相似 ,但对血脂的调节 ,泰脂安组效果更优。

英文摘要:

Objective: To grasp the therapeutic effect of Taizhi′an (TZA) in lowering blood lipid level. Methods: Three hundred patients with hyperlipidemia were randomly divided adopting numerical table method into 7 groups, the Taizhi′an group (A, n=90), the half dose Fenofibrate plus Taizhi′an group (B, n=30), the full dose Fenofibrate group (C, n=30), the half dose Simvastatin plus Taizhi′an group (D, n=30), the full dose Simvastatin group (E, n=30), the Zhibituo group (F, n=60) and the Xuezhikang group (G, n=30). The effect in different groups were compared after 8 weeks treatment. Results: In group A, the total cholesterol (TC) lowered by 12.7%, triglyceride (TG) lowered by 22.1% and the high density lipoprotein cholesterol (HDL C) increased by 13.1%, the total effective rate being 82%. The therapeutic effect in group B was similar to that in group C, and that in group D was similar to that in group E (P>0 05). The therapeutic effect of Taizhi′an was similar to that of Xuezhikang and Zhibituo, but was better than Zhibituo in lowering TG, LDL C and increasing HDL C, and better than Xuezhikang in lowering TG and increasing HDL C (P<0 05). Conclusion: When Taizhi′an used in combination with half dose Simvastatin, it could not only enhance the blood lipid regulatory effect of Simvastatin but also reduce the dosage used and alleviate its adverse reaction. Compared with Xuezhikang and Zhibituo, Taizhi′an got the similar therapeutic effect, but was superior in regulating blood lipids.

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