蒲参胶囊治疗高脂血症的临床疗效评价

作者	单位
刘宗莲	中国中医研究院广安门医院北京 100053
吴圣贤	中国中医研究院广安门医院北京 100053
高改地	中国中医研究院广安门医院北京 100053

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中文摘要:

目的观察蒲参胶囊对原发性高脂血症的调脂作用。方法 240例原发性高脂血症患者随机分成两组,治疗组服用蒲参胶囊另加脂必妥片安慰剂;对照组服用脂必妥片另加蒲参胶囊安慰剂,两组疗程均为4周。观察其疗效及两组血脂(TC、TG、LDL-C和HDL-C)、血黏度变化等指标。结果治疗组总有效率(76.3％)优于对照组(48.7％,P<0.01);治疗后两组TC、TG、LDL-C明显降低,HDL-C明显升高(P<0.05或P<0.01);且TG治疗组明显优于对照组(P<0.01);治疗组全血高、低切黏度有一定降低(P<0.01)。结论蒲参胶囊对原发性高脂血症患者(尤其是TG升高者)有较好的调脂作用,且有一定的降低血黏度的作用。

英文摘要:

To explore the therapeutic effect of Pushen capsule (PSC) in treating primary hyperlipidemia. Methods Two hundred and forty patients with primary hyperlipidemia were randomly divided into two groups, the 120 patients in the treated group treated with PSC (4 capsules, tid) and the 120 patients in the control group treated with Zhibituo tablet (3 tablets, tid), and they were administered at the same time with Zhibituo placebo. The therapeutic course for both groups was 4 weeks. The therapeutic effect and the effects on blood lipids and viscosity were observed. Results The effective rate in the treated group was 16.3% , which was significantly higher than that in the control group (48.7% , P<0.01). PSC showed a significant lowering effect on TC, TG and LDL-C and raising effect on HDL-C, and the effect in lowering TG was significantly better than that of Zhibituo (P<0.01). PSC also showed a certain effect in decreasing whole blood viscosity of both high-sheared and low-sheared viscosity. Conclusion Pushen capsule has promising blood lipid regulating effect in patients with hyperlipidemia, and some effects in lowering the blood viscosity.

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