百令胶囊在肾移植术后应用的临床研究

作者	单位
孙明	四川大学华西医院泌尿外科成都610041
杨宇如	四川大学华西医院泌尿外科成都610041
卢一平	四川大学华西医院泌尿外科成都610041
高锐	四川大学华西医院泌尿外科成都610041
王莉	四川大学华西医院泌尿外科成都610041
王佳	四川大学华西医院泌尿外科成都610041
唐科仕	四川大学华西医院泌尿外科成都610041

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中文摘要:

目的观察和总结肾移植术后应用百令胶囊 (冬虫夏草菌丝体干粉制剂 )的免疫抑制效果 ,对机体其他系统的影响 ,并探讨其可能的作用机理。方法同种异体肾移植术后受者 12 1例 ,随机分为两组 ,A组 6 4例使用环孢素A加泼尼松加硫唑嘌呤 ,B组 5 7例使用环孢素A加泼尼松加百令胶囊为免疫抑制方案 ,随访 1～ 2年 ,术后 1个月内每周检测血常规、尿常规 ,肝肾功能 ,血电解质、血糖、血脂及尿酸等 2次 ,以后根据情况适当检测和复查。结果肾存活率及排斥反应发生率、肾功恢复状况、血电解质和血糖水平值两组比较差异无显著性。B组尿红、白细胞数量、血谷草转氨酶和谷丙转氨酶、血总胆固醇、血清尿酸、感染发生率显著少于A组 (P <0 0 5或P <0 0 1) ;B组血高密度脂蛋白胆固醇和血清总蛋白、血清白蛋白 ,血红细胞、白细胞数量显著高于A组 (P <0 0 5 )。结论百令胶囊可以有效预防肾移植术后排斥反应、保护肝肾功能 ,刺激造血 ,改善低蛋白血症和高脂血症 ,减少感染等 ,是一种较理想的器官移植免疫抑制剂

英文摘要:

Objective To observe and assess the immunosuppressive effect of applying Bailing capsule (BLC, a dry powder preparation of Cordyceps sinensis mycelia), after renal transplantation, its influence on other systems of organism, and to explore the possible therapeutic mechanism. Methods One hundred and twenty one recipients of renal homo allograft were randomly divided into two groups. The 64 cases in Group A was treated with cyclosporin A (Cs A)+prednisone (pred) +azathioprine (Aza), the 57 in Group B treated with Cs A+pred+BLC. They were followed up for 1-2 year by checking up blood routine, urine routine, liver and renal function, blood electrolytes, glucose and lipids, and uric acid for 2 times every week in the first month after transplantation, followed by proper re examination of these items according to various condition. Results There was no significant difference between the two groups in aspects of graft survival rate, occurrence of reject reaction, renal function recovery, blood electrolytes and blood glucose levels. However, as compared with Group A, in Group B, levels of urinary erythrocytes and leucocytes, blood alanine transaminase (ALT), aspartate aminotransferase (AST), total cholesterol, uric acid as well as the incidence of infection were significantly lower, and blood high density lipoprotein, serum total protein, albumin, RBC and WBC count were significantly higher. Conclusion BLC could effectively prevent the reject response after renal transplantation, protect renal and liver function, stimulate hemopoietic function, improve hypoproteinemia and hyperlipidemia, reduce the infection, etc., therefore, it is an ideal immunosuppressor after organ transplantation.

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