补锌联合金叶败毒颗粒治疗人巨细胞病毒感染的临床观察

作者	单位
李丹	华中科技大学同济医学院附属同济医院妇产科武汉430030
闻良珍	华中科技大学同济医学院附属同济医院妇产科武汉430030
袁慧	华中科技大学同济医学院附属同济医院妇产科武汉430030
刘继晓	华中科技大学同济医学院附属同济医院妇产科武汉430030
刘楠	华中科技大学同济医学院附属同济医院妇产科武汉430030

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中文摘要:

目的探讨补锌联合中药治疗人巨细胞病毒(HCMV)感染的疗效。方法将HCMV IgM阳性患者14 0例随机分为4组,即对照组(单纯服用金叶败毒颗粒)及大、中、小剂量治疗组(口服金叶败毒颗粒及30、2 0、10mg/d的葡萄糖酸锌片) ,每组均为35例,观察HCMV IgM的转阴率。结果对照组与小剂量治疗组比较,差异无显著性(P >0 .0 5) ;中、大剂量治疗组组间比较,差异无显著性(P >0 0 5) ;对照组与中、大剂量治疗组比较,HCMV IgM转阴率明显降低(χ2 =9 2 .85,P =0. 0 0 2 )。结论补锌联合中药治疗可明显提高HCMV IgM阳性的转阴率,给予2 0mg/d葡萄糖酸锌片联合中药治疗是最佳剂量选择。

英文摘要:

ObjectiveTo explore the clinical efficacy of the combined therapy of zinc supplement and Jinye Baidu granule (JBG) on human cytomegalovirus (HCMV) infection. MethodsOne hundred and forty patients with positive HCMV-IgM were randomly divided into four groups, with 35 cases in each group, that is, the control group (only medicated with JBG), the high-, moderate- and low-dose zinc combined groups (treated with JBG combined with zinc gluconate tablet at dose of 30mg, 20mg, 10mg every day respectively). The negative conversion rate of HCMV-IgM was observed. ResultsInsignificant difference in the negative conversion rate was shown in comparison of the control group with the low dose group (P>0.05), and in comparison of the high dose with the moderate dose group (P>0.05); however, the rate was significantly lower in the control group than that in the moderate dose and high dose group (P<0.05). ConclusionCombined therapy of zinc supplement and JBG can significantly increase the negative conversion rate of HCMV-IgM. The optimal dosage of zinc gluconate tablet was 20 mg once a day.

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