乳腺增生病中医证型与血管生成关系的临床观察

作者	单位
宋爱莉	山东中医药大学附属医院乳腺外科
孙贻安	山东中医药大学附属医院乳腺外科
杨毅	山东中医药大学附属医院乳腺外科
叶林	山东中医药大学附属医院乳腺外科
李静蔚	山东中医药大学
刘晓菲	山东中医药大学

摘要点击次数: 1622

全文下载次数: 1571

中文摘要:

目的研究乳腺增生病不同中医证型与血管生成的关系,探讨乳腺增生病证型诊断的客观标准。方法14 0例乳腺增生病患者,按中医辨证类型分为3组,活检后观察病理分型、分级及血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)、碱性成纤维细胞生长因子(basicfibroblastgrowthfactor,bFGF)、微血管密度(microvasculardensity ,MVD)的表达情况。结果14 0例乳腺增生病患者中,不同中医证型的病理分级及VEGF、bFGF、MVD表达差异有显著性(P <0 . 0 5) ;痰瘀互结型与肝郁气滞型、冲任失调型比较,非典型增生所占比例高,MVD计数多,VEGF与bFGF表达程度高(P <0 .0 5)。结论乳腺增生病中医证型与血管活性及增生程度有相关性,病理特征及VEGF、bFGF、MVD表达可作为乳腺增生病中医证型研究、疗效判定的客观化指标。

英文摘要:

ObjectiveTo study the relationship between angiogensis and TCM Syndrome type of cyclomastopathy (CMP) to investigate the objective standardization of TCM Syndrome diagnosis of the disease. MethodsOne hundred and forty patients with CMP were divided into three groups according to TCM syndrome typing. The pathological type, grade and expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvascular density (MVD) in mammary biopsy were observed. ResultsThe expressions of VEGF, bFGF and MVD was different in CMP patients of different TCM types and pathological grades (P<0.05). The proportion of atypical proliferation, the count of MVD and the expression of VEGF and bFGF were higher in patients of phlegm and stasis type than those in Gan stagnation caused Qi-stagnation type and Chong and Ren meridians disorder type. ConclusionTCM Syndrome type of CMP patients is related with vascular activity and grade of angiogensis. The pathological characteristics of mammary tissue and expression of VEGF, bFGF and MVD can be regarded as the objective indexes of TCM typing and clinical efficacy evaluation for CMP.

关闭