透明质酸钠关节内注射配合三花膏外敷治疗膝骨性关节炎的临床观察

Clinical Observation on Effect of Intra-articular Injection of Sodium Hyaluronate Accompanied with External Application of Sanhua Ointment for Knee Osteoarthritis

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DOI：

中文关键词: 透明质酸钠关节内注射三花膏外敷膝骨性关节炎 Lysholm功能评分

英文关键词:sodium hyaluronate intra-articular injection Sanhua ointment external application knee osteoarthritis Lysholm’s function scoring

基金项目:西安市科技攻关计划项目(No.GG04123)

作者	单位
许鹏	西安交通大学环境与疾病相关基因教育部重点实验室地方病研究所
郭雄	西安交通大学环境与疾病相关基因教育部重点实验室地方病研究所
靳卫章	西安市红十字会医院骨关节科
姚建锋	西安市红十字会医院骨关节科
张银刚	西安交通大学环境与疾病相关基因教育部重点实验室地方病研究所
蔡乾坤	西安市红十字会医院骨关节科

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中文摘要:

目的观察透明质酸钠(SH)关节内注射配合中药三花膏外敷治疗膝骨性关节炎的临床疗效。方法将112例膝骨性关节炎患者随机分为两组,Ⅰ组(54例)采用单纯膝关节内注射SH治疗,Ⅱ组(58例)采用关节内注射SH配合三花膏外敷治疗,对两组患者治疗前后膝关节整体情况按照Lysholm功能评分标准作评分比较。结果治疗第2周、第5周、治疗后3个月及1年的膝关节功能评分结果显示,两组膝关节评分值均较治疗前显著升高(P<0.05),且3个月内随时间的延长而不断增高,两组同期比较,Ⅱ组的评分值明显高于Ⅰ组(P<0.05);治疗后1年,Ⅰ组总有效率为81.5%,Ⅱ组总有效率为96.6%,Ⅱ组高于Ⅰ组(P<0.05);Ⅱ组患者症状、体征初次改善时间明显早于Ⅰ组,不良反应症状消退速度亦快于Ⅰ组。结论关节内注射SH配合三花膏外敷治疗膝骨性关节炎的临床疗效优于单用膝关节内注射SH者。

英文摘要:

ObjectiveTo observe clinical efficacy of intra-articular injection of Sodium hyaluronate (SH) accompanied with external application of Sanhua ointment (SHO) for knee osteoarthritis. MethodsOne hundred and twelve patients with osteoarthritis were randomly divided into two groups, Group Ⅰ was treated with SH and Group Ⅱ was treated with SH plus SHO. The entire condition of knee joint in the two groups were compared before and after treatment according to Lysholm’s function scoring. ResultsThe functional score in the two groups at the 2nd week, 5th week, 3rd month and end of 1st year of the treatment course were significantly higher than that before treatment (P<0.05), and the scores continuously increased within the first 3 months of treatment. Comparison of scores between the two groups showed that scores in GroupⅡwas significantly higher than those in GroupⅠat the corresponding period. The total effective rate after 1 year treatment in GroupⅡ was higher than that in Group Ⅱ (81.5% vs 96.6%, P<0.05). In GroupⅡ, the initial time of symptom improving was earlier and the adverse effect disappeared more quickly than those in Group Ⅰ markedly. ConclusionThe efficacy of combined therapy of intra-articular injection of SH and SHO for knee osteoarthritis was superior to that of intra-articular injection of SH only.

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