| 刘江,施柏年,何建方,戴利成.氧化苦参碱对慢性乙肝和肝硬化患者血清MMP-2和TIMP-2的影响[J].中国中西医结合杂志,2005,(11):989-992 |
| 氧化苦参碱对慢性乙肝和肝硬化患者血清MMP-2和TIMP-2的影响 |
| Effect of Oxymatrine on Serum Matrix Metalloproteinase-2 and its Inhibitor in Patients with Chronic Hepatitis B and Liver Cirrhosis |
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| 中文关键词: 氧化苦参碱 慢性乙型肝炎 肝硬化 基质金属蛋白酶-2 基质金属蛋白酶-2组织抑制因子 |
| 英文关键词:oxymatrine chronic hepatitis B liver cirrhosis matrix metalloproteinase-2 issue inhibitor of metalloprotienase-2 |
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| 中文摘要: |
| 目的观察氧化苦参碱对慢性乙型病毒性肝炎(简称慢乙肝)和乙型肝炎后肝硬化(简称肝硬化)患者血清基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-2组织抑制因子(TI MP-2)以及肝纤维化指标〔透明质酸(HA)、层粘连蛋白(LN)和Ⅳ型胶原(ⅣC)〕的影响。方法慢乙肝(36例)和肝硬化(36例)患者用氧化苦参碱治疗前后采用ELISA方法检测血清MMP-2、TI MP-2,采用放射免疫法检测HA、LN、ⅣC的变化,并分析MMP-2、TI MP-2和肝纤维化指标之间相关性。结果氧化苦参碱能降低慢乙肝中、重度和肝硬化Child-pugh A、B、C级血清HA、LN、ⅣC水平及血清MMP-2水平(与本组治疗前比较,P<0.05)。血清MMP-2、TI MP-2水平分别与HA、LN、ⅣC均有良好相关性(P<0.01)。结论MMP-2、TI MP-2可用来评价纤维化情况,氧化苦参碱有一定抗肝纤维化作用。 |
| 英文摘要: |
| ObjectiveTo observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and Ⅳtype collagen (ⅣC).Methods Changes of all the above-mentioned indexes in patients with CHB (n=36) and LC (n=36)before and after treatment were determined, and the relationship of MMP-2 and TIMP-2 with liver fibrosis indexes were analyzed. ResultsOxymatrine could decrease the levels of MMP-2, HA, LN and ⅣC in patients with severe or moderate CHB and LC of Child-pugh A, B and C grade, as compared with the data before treatment (P<0.05). Serum level of MMP-2 and TIMP-2 was well correlated with the levels of liver cirrhosis indexes. ConclusionMMP-2 and TIMP-2 can be used as a reference for evaluating the degree of LC, and oxymatrine has a certain anti-LC effect. |
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