扶正培本治则方药调节肿瘤微环境免疫与血管正常化的思路研究

A Concept of Regulating Tumor Microenvironment Immune and Normalizing Angiogenesis by Chinese Medicine Drug Therapy for Supporting Zheng-qi to Prop up Root

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中文关键词: 肿瘤微环境免疫血管正常化时间窗扶正培本中药抗血管生成疗效评价

英文关键词:immunity in tumor microenvironment normalization window for tumor vasculature supporting body resistance evaluation on therapeutic effect of antiangiogenic therapy with the traditional Chinese drug

基金项目:

作者	单位
熊露	中国中医科学院广安门医院肿瘤科
田少霞	陕西省咸阳市中医肿瘤医院

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中文摘要:

"血管正常化时间窗"的发现是目前抗肿瘤血管生成领域研究的热点之一。将现代肿瘤微环境学说与抗肿瘤血管生成领域研究热点相结合,提出应用扶正培本治则方药调节肿瘤微环境免疫与血管的正常化的理论构想,主张通过扶正培本为主导的中药复方对肿瘤"微环境免疫与血管正常化"的调节作用与机制研究,探索中晚期非小细胞肺癌中医药抗血管生成治疗"血管正常化时间窗",为阐明扶正培本方药为主导的抗肿瘤侵袭与转移机制,联合放化疗最佳时机的选择,中医药抗血管生成疗效评价方法,提供初步的理论与实验依据,指导临床用药。

英文摘要:

Antiangiogenic therapy can generate a "normalization window" for tumor vasculature. This normalization process prunes immature vessels and improves the integrity and function of the remaining vasculature by enhancing the perivascular cell and basement membrane coverage in tumor, therefor creates a window of opportunity for improved sensitivity to ionizing radiation and the delivery of chemotherapeutic drugs. It provides a rational basis for the combination therapy of traditional Chinese drugs with radiation and perhaps other forms of chemotherapy. Antiangiogenic therapy with the traditional Chinese drug interfering in the the mechanisms of the normalization window in humans maybe harness a new approach to improve the sensitivity of tumors to radio- and chemotherapy.

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