5种血瘀证亚型家兔模型球结膜微循环改变的比较

目的观察5种血瘀证亚型兔球结膜微循环改变，分析5种血瘀证的不同特性。方法将60只日本大耳兔按随机分组法分为气虚血瘀组、气滞血瘀组、寒凝血瘀组、热毒血瘀组、外伤血瘀组及正常对照组，每组10只。造模前后分别观察兔球结膜微循环的变化。结果与正常对照组比较，5种血瘀证球结膜微循环总积分明显升高（P<0.05）；5种血瘀证组间比较，差异无统计学意义（P>0.05），但在具体分项积分中，5种血瘀证组间比较，差异有统计学意义（P<0.05），热毒血瘀证组以血管增粗、管壁渗血为主；气虚血瘀证组以缺血、部分囊状扩张、部分血管怒张、扭曲为主；气滞血瘀证组以部分血管扭曲，瘤样改变，血流速度减慢为主；外伤血瘀证组以血管扭曲、充血、血管怒张、血流速度减慢为主；寒凝血瘀证组以血管扭曲、缺血、色调暗为主。结论 5种血瘀证的微循环改变具有不同特点，可以反映5种血瘀证不同特性。

英文摘要:

Objective To observe changes of bulbar conjunctival microcirculation in rabbits of five kinds subtypes of blood stasis syndrome （BSS）， and to analyze their different properties. MethodsTotally 60 Japanese big ear rabbits were randomly divided into six groups， i.e.， qi deficiency blood stasis group， qi stagnation blood stasis group， cold coagulation blood stasis group， heat toxin blood stasis group， external injury blood stasis group， and the normal control group，10 in each group. Changes of rabbit bulbar conjunctiva microcirculation were observed before and after modeling. Results Compared with the normal control group， the total integral of bulbar conjunctiva microcirculation obviously increased in the 5 BSS groups （P<0.05）. There was no statistical difference among the 5 BSS groups （P>0.05）. But there was statistical difference in any concrete integral among the 5 BSS groups （P<0.05）. Thickening blood vessels and errhysis of vascular walls were dominant in the heat toxin blood stasis group. Ischemia， partial cystic dilatation， vascular engorgement and twist were dominant in the qi deficiency blood stasis group. Partial vascular buckling， aneurysmal changes， flow velocity slowed down were dominant in the qi stagnation blood stasis group. Vascular buckling， hyperemia， vascular engorgement， blood flow slowed down were dominant in the external injury blood stasis group. Vascular buckling， ischemia， dark color were dominant in the cold coagulation blood stasis group. Conclusion Changes of bulbar conjunctival microcirculation were different in 5 kinds of BSS types， which could reflect their various features.

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